Zero-Controls

Zero-Controls: The Foundation of Precise Diagnostics

Negative matrices and negative controls are indispensable tools in In-Vitro Diagnostics (IVD) R&D. Serving as defined reference points without target analytes, they ensure specific, precise test performance free of cross-reactions. Without these "zero references," signal and noise in complex biological samples cannot be reliably separated.

Why Do We Need Zero-Controls?

In diagnostic development, the absence of a signal in the negative state determines clinical validity. Zero-controls fulfill three core tasks:

• – Preventing False Positives: They prove assay specificity by ensuring the test only responds when the target pathogen or biomarker is actually present.
• – Managing Matrix Effects: Biological samples (serum, plasma, urine) contain thousands of proteins and lipids that can cause non-specific binding. The negative matrix measures and minimizes this background noise.
• – Validating Reagents: Controls detect contamination or systematic errors early in the test setup.

Standard – all products can be customized / produced OEM

Special testing and screening upon customer's request. TRINA BIOREACTIVES can access most testing systems and reagents through our partner laboratory network.

Viral testing

The material have been single donation tested at the blood bank with FDA/EU approved test procedures and found non-reactive for HBAg, negative for anti-HIV 1 + 2 and anti-HCV. Donors tested negative for Syphilis. The material has been tested according to FDA/EU approved procedures with PCR and found HIV-1 RNA, HCV RNA and HBV DNA non-reactive (single donor or pool testing).

Packaging